Reaching within a dynamic virtual environment

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Constraints on the Neutrino Mass from SZ Surveys

Statistical measures of galaxy clusters are sensitive to neutrino masses in the sub-eV range. We explore the possibility of using cluster number counts from the ongoing PLANCK/SZ and future cosmic-variance-limited surveys to constrain neutrino masses from CMB data alone. The precision with which the total neutrino mass can be determined from SZ number counts is limited mostly by uncertainties in the cluster mass function and intracluster gas evolution; these are explicitly accounted for in our analysis. We find that projected results from the PLANCK/SZ survey can be used to determine the total neutrino mass with a (1\sigma) uncertainty of 0.06 eV, assuming it is in the range 0.1-0.3 eV, and the survey detection limit is set at the 5\sigma significance level. Our results constitute a significant improvement on the limits expected from PLANCK/CMB lensing measurements, 0.15 eV. Based on expected results from future cosmic-variance-limited (CVL) SZ survey we predict a 1\sigma uncertainty of 0.04 eV, a level comparable to that expected when CMB lensing extraction is carried out with the same experiment. A few percent uncertainty in the mass function parameters could result in up to a factor \sim 2-3 degradation of our PLANCK and CVL forecasts. Our analysis shows that cluster number counts provide a viable complementary cosmological probe to CMB lensing constraints on the total neutrino mass.Comment: Replaced with a revised version to match the MNRAS accepted version. arXiv admin note: text overlap with arXiv:1009.411

The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD

© 2018, The Author(s). Genome-wide mRNA profiling in lung tissue from human and animal models can provide novel insights into the pathogenesis of chronic obstructive pulmonary disease (COPD). While 6 months of smoke exposure are widely used, shorter durations were also reported. The overlap of short term and long-term smoke exposure in mice is currently not well understood, and their representation of the human condition is uncertain. Lung tissue gene expression profiles of six murine smoking experiments (n = 48) were obtained from the Gene Expression Omnibus (GEO) and analyzed to identify the murine smoking signature. The “human smoking” gene signature containing 386 genes was previously published in the lung eQTL study (n = 1,111). A signature of mild COPD containing 7 genes was also identified in the same study. The lung tissue gene signature of “severe COPD” (n = 70) contained 4,071 genes and was previously published. We detected 3,723 differentially expressed genes in the 6 month-exposure mice datasets (FDR <0.1). Of those, 184 genes (representing 48% of human smoking) and 1,003 (representing 27% of human COPD) were shared with the human smoking-related genes and the COPD severity-related genes, respectively. There was 4-fold over-representation of human and murine smoking-related genes (P = 6.7 × 10−26) and a 1.4 fold in the severe COPD -related genes (P = 2.3 × 10−12). There was no significant enrichment of the mice and human smoking-related genes in mild COPD signature. These data suggest that murine smoke models are strongly representative of molecular processes of human smoking but less of COPD

Gravitational wave searches for ultralight bosons with LIGO and LISA

Ultralight bosons can induce superradiant instabilities in spinning black holes, tapping their rotational energy to trigger the growth of a bosonic condensate. Possible observational imprints of these boson clouds include (i) direct detection of the nearly monochromatic (resolvable or stochastic) gravitational waves emitted by the condensate, and (ii) statistically significant evidence for the formation of \u201choles\u201d at large spins in the spin versus mass plane (sometimes also referred to as \u201cRegge plane\u201d) of astrophysical black holes. In this work, we focus on the prospects of LISA and LIGO detecting or constraining scalars with mass in the range ms 08[10 1219,10 1215]\u2009\u2009eV and ms 08[10 1214,10 1211]\u2009\u2009eV, respectively. Using astrophysical models of black-hole populations calibrated to observations and black-hole perturbation theory calculations of the gravitational emission, we find that, in optimistic scenarios, LIGO could observe a stochastic background of gravitational radiation in the range ms 08[2 710 1213,10 1212]\u2009\u2009eV, and up to 104 resolvable events in a 4-year search if ms 3c3 710 1213\u2009\u2009eV. LISA could observe a stochastic background for boson masses in the range ms 08[5 710 1219,5 710 1216], and up to 3c103 resolvable events in a 4-year search if ms 3c10 1217\u2009\u2009eV. LISA could further measure spins for black-hole binaries with component masses in the range [103,107]M 99, which is not probed by traditional spin-measurement techniques. A statistical analysis of the spin distribution of these binaries could either rule out scalar fields in the mass range 3c[4 710 1218,10 1214]\u2009\u2009eV, or measure ms with ten percent accuracy if light scalars in the mass range 3c[10 1217,10 1213]\u2009\u2009eV exist

The Origin of the Universe as Revealed Through the Polarization of the Cosmic Microwave Background

Modern cosmology has sharpened questions posed for millennia about the origin of our cosmic habitat. The age-old questions have been transformed into two pressing issues primed for attack in the coming decade: How did the Universe begin? and What physical laws govern the Universe at the highest energies? The clearest window onto these questions is the pattern of polarization in the Cosmic Microwave Background (CMB), which is uniquely sensitive to primordial gravity waves. A detection of the special pattern produced by gravity waves would be not only an unprecedented discovery, but also a direct probe of physics at the earliest observable instants of our Universe. Experiments which map CMB polarization over the coming decade will lead us on our first steps towards answering these age-old questions.Comment: Science White Paper submitted to the US Astro2010 Decadal Survey. Full list of 212 author available at http://cmbpol.uchicago.ed

Spectral Distortions of the CMB as a Probe of Inflation, Recombination, Structure Formation and Particle Physics

Following the pioneering observations with COBE in the early 1990s, studies of the cosmic microwave background (CMB) have focused on temperature and polarization anisotropies. CMB spectral distortions - tiny departures of the CMB energy spectrum from that of a perfect blackbody - provide a second, independent probe of fundamental physics, with a reach deep into the primordial Universe. The theoretical foundation of spectral distortions has seen major advances in recent years, which highlight the immense potential of this emerging field. Spectral distortions probe a fundamental property of the Universe - its thermal history - thereby providing additional insight into processes within the cosmological standard model (CSM) as well as new physics beyond. Spectral distortions are an important tool for understanding inflation and the nature of dark matter. They shed new light on the physics of recombination and reionization, both prominent stages in the evolution of our Universe, and furnish critical information on baryonic feedback processes, in addition to probing primordial correlation functions at scales inaccessible to other tracers. In principle the range of signals is vast: many orders of magnitude of discovery space could be explored by detailed observations of the CMB energy spectrum. Several CSM signals are predicted and provide clear experimental targets, some of which are already observable with present-day technology. Confirmation of these signals would extend the reach of the CSM by orders of magnitude in physical scale as the Universe evolves from the initial stages to its present form. The absence of these signals would pose a huge theoretical challenge, immediately pointing to new physics.Comment: Astro2020 Science White Paper, 5 pages text, 13 pages in total, 3 Figures, minor update to reference

Young and Intermediate-age Distance Indicators

Distance measurements beyond geometrical and semi-geometrical methods, rely mainly on standard candles. As the name suggests, these objects have known luminosities by virtue of their intrinsic proprieties and play a major role in our understanding of modern cosmology. The main caveats associated with standard candles are their absolute calibration, contamination of the sample from other sources and systematic uncertainties. The absolute calibration mainly depends on their chemical composition and age. To understand the impact of these effects on the distance scale, it is essential to develop methods based on different sample of standard candles. Here we review the fundamental properties of young and intermediate-age distance indicators such as Cepheids, Mira variables and Red Clump stars and the recent developments in their application as distance indicators.Comment: Review article, 63 pages (28 figures), Accepted for publication in Space Science Reviews (Chapter 3 of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Age

Geophysical monitoring and reactive transport modeling of ureolytically-driven calcium carbonate precipitation

Ureolytically-driven calcium carbonate precipitation is the basis for a promising in-situ remediation method for sequestration of divalent radionuclide and trace metal ions. It has also been proposed for use in geotechnical engineering for soil strengthening applications. Monitoring the occurrence, spatial distribution, and temporal evolution of calcium carbonate precipitation in the subsurface is critical for evaluating the performance of this technology and for developing the predictive models needed for engineering application. In this study, we conducted laboratory column experiments using natural sediment and groundwater to evaluate the utility of geophysical (complex resistivity and seismic) sensing methods, dynamic synchrotron x-ray computed tomography (micro-CT), and reactive transport modeling for tracking ureolytically-driven calcium carbonate precipitation processes under site relevant conditions. Reactive transport modeling with TOUGHREACT successfully simulated the changes of the major chemical components during urea hydrolysis. Even at the relatively low level of urea hydrolysis observed in the experiments, the simulations predicted an enhanced calcium carbonate precipitation rate that was 3-4 times greater than the baseline level. Reactive transport modeling results, geophysical monitoring data and micro-CT imaging correlated well with reaction processes validated by geochemical data. In particular, increases in ionic strength of the pore fluid during urea hydrolysis predicted by geochemical modeling were successfully captured by electrical conductivity measurements and confirmed by geochemical data. The low level of urea hydrolysis and calcium carbonate precipitation suggested by the model and geochemical data was corroborated by minor changes in seismic P-wave velocity measurements and micro-CT imaging; the latter provided direct evidence of sparsely distributed calcium carbonate precipitation. Ion exchange processes promoted through NH4+ production during urea hydrolysis were incorporated in the model and captured critical changes in the major metal species. The electrical phase increases were potentially due to ion exchange processes that modified charge structure at mineral/water interfaces. Our study revealed the potential of geophysical monitoring for geochemical changes during urea hydrolysis and the advantages of combining multiple approaches to understand complex biogeochemical processes in the subsurface

FALCON: A phase III randomised trial of fulvestrant 500 mg vs. anastrozole for hormone receptor-positive advanced breast cancer

Background: This Phase III, randomised, double-blind, multicentre trial (FALCON; NCT01602380) compared the selective estrogen receptor (ER) degrader (SERD) fulvestrant with anastrozole in patients with ER- and/or progesterone receptor-positive locally advanced or metastatic breast cancer who had not received prior hormonal therapy. Methods: Patients were randomised 1:1 to fulvestrant (500 mg IM on Days 0, 14, 28, then each 28 days) or anastrozole (1 mg daily). The primary endpoint was progression-free survival (PFS), assessed via RECIST 1.1, surgery/radiotherapy for disease worsening, or death. Secondary endpoints were: overall survival (OS); objective response rate (ORR, complete response [CR] or partial response [PR]); duration of response (DoR); expected DoR (EDoR); clinical benefit rate (CBR; CR, PR, or stable disease ≥24 weeks); duration of clinical benefit (DoCB); expected DoCB (EDoCB); health-related quality of life (HRQoL); and safety

WFIRST: The Essential Cosmology Space Observatory for the Coming Decade

Two decades after its discovery, cosmic acceleration remains the most profound mystery in cosmology and arguably in all of physics. Either the Universe is dominated by a form of dark energy with exotic physical properties not predicted by standard model physics, or General Relativity is not an adequate description of gravity over cosmic distances. WFIRST emerged as a top priority of Astro2010 in part because of its ability to address the mystery of cosmic acceleration through both high precision measurements of the cosmic expansion history and the growth of cosmic structures with multiple and redundant probes. We illustrate in this white paper how mission design changes since Astro2010 have made WFIRST an even more powerful dark energy facility and have improved the ability of WFIRST to respond to changes in the experimental landscape. WFIRST is the space-based probe of DE the community needs in the mid-2020s